ABSTRACT
The aim of this COVID-19 Practical Manual for the prevention, detection, control and surveillance of SARS-CoV-2 is to standardize and regulate the best strategy for the prevention and control of SARS-CoV-2 infections. All of this to provide better care quality to patients and their families/caregivers, and to promote a safe working environment for health personnel within the institution. The manual has been prepared with the aim of guiding health personnel in decision-making for the prevention, detection, control and surveillance of SARS-CoV-2 infections. This document describes various multidisciplinary care algorithms in different scenarios, considering the recommendations for isolation, use of personal protective equipment, transfer within various services in the hospital, admission to procedures and recommendations for healthcare personnel. Copyright © 2022 Hospital Infantil de Mexico Federico Gomez. Publicado por Permanyer.
ABSTRACT
Introduction: It was recently observed and described an association between a pediatric hyperinflammatory state and the infection by SARS-CoV-2 which was named Multisystem inflammatory syndrome in children related to COVID-19 (PIMS- TS) or Multisystem inflammatory syndrome (in children) MIS-C. Objectives: We aimed our study at describing the clinical features, epidemiologic characteristics, management, and prognosis. Methods: This is a retrospective, descriptive and observational study performed at the Hospital Infantil de Mexico Federico Gomez, a thirdlevel children's hospital in Mexico City. The study includes all the cases that met criteria for PIMS-TS/MIS-C of the RCPCH, WHO, and/or CDC, that were diagnosed and treated between March 2020 and March 2021. We identified a total of 41 cases. Results: The depicted table describe the demographics of our studied population. The highest incidence was seen in previously healthy, school-aged children. No differences were noted based on sex. In 50% of the cases, there was history of exposure to COVID-19. 7.3% of patients had an associated comorbidity. The SARS-CoV2 was isolated from CSF in one patient with PIMS. There were no documented cases of macrophage activation syndrome (MAS). While coagulopathy was observed, there were no cases of disseminated intravascular coagulation (DIC). These results are consistent with the results reported by Hoste L et al. Eur J Pediatr. 2021. Conclusion: The present study depicts the experience of our institution with the new nosological entity named PIMS. We highlight the null mortality, the effectiveness of steroids and gammaglobulin in lieu of biologic therapy as part of the management, and the predominance of previously healthy patients without significant comorbidities. We consider this a broad evaluation, as our sample size consisted of 41 patients from the same location.